Ali Kermanizadeh,1,2 Leagh G Powell,1 Vicki Stone,1 Peter Møller2
1NanoSafety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; 2Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Abstract: The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications.
Keywords: nanomedicine, oral route of delivery, nanomaterials, nano-stabilized solid drugs