No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19

#1 by Lesley , Thu Dec 17, 2020 8:05 pm

Georgia Wilson Jones, Marco P Monopoli, Luisa Campagnolo, Antonio Pietroiusti, Lang Tran & Bengt Fadeel

There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.

Keywords: bio-mimicking particlescoronaviruscytokine stormnanomedicinenanosafety

Full paper available here: https://www.futuremedicine.com/doi/10.2217/nnm-2020-0286

Lesley  
Lesley
Posts: 37
Date registered 12.18.2019


   

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